In Explaining Unexplained Illnesses, Dr. Pall outlines a new disease paradigm: a vicious cycle of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO¯) and the effects on various tissues. The cycle is extremely complex but involves what he describes as "well-established" and "known biochemical sequences."
The symptoms of the multisystem illnesses (his term for environmental illnesses) differ from one another according to which tissues are affected. In chronic fatigue syndrome, the NO/ONOO¯ cycle affects the mitochondria; in fibromyalgia, the cycle affects the thalamus; in post-traumatic stress disorder, the cycle affects the hippocampus; and in multiple chemical sensitivity, the cycle affects specific neurotransmitter receptors and causes neural sensitization.
Dr. Pall's book is closely argued from the evidence of hundreds of studies in biochemical and medical journals.
Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained'
Q&A with Martin L. Pall, PhD
with Martin L. Pall, PhD-July 6, 2007:
Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia
& Suggested Protocol
Conversation with MCS Researcher Martin Pall
by Linda Powers, Townsend Letter for Doctors and Patients, Aug.-Sept. 2005
Martin Pall on ResearchGate
Sensitization and Stimulation by Peroxynitrite, Nitric Oxide, and
Organic Solvents as the Mechanism of Chemical Sensitivity in
Multiple Chemical Sensitivity
by Martin L. Pall, The FASEB Journal, 2002 (abstract)
Oxide/Peroxynitrite Theory of Multiple Chemical Sensitivity: Central
Role of N-Methyl-D-Aspartate Receptors in the Sensitivity
by Martin L. Pall, Envronmental Health Perspectives, September 2003
Receptor as a Putative Target of Diverse Chemicals in Multiple
by Julius H. Anderson and Martin L. Pall, Archives of Environmental Health, 2004 (abstract)