In Explaining Unexplained Illnesses, Dr. Pall outlines a new disease paradigm: a vicious cycle of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO¯) and the effects on various tissues. The cycle is extremely complex but involves what he describes as "well-established" and "known biochemical sequences."
The symptoms of the multisystem illnesses (his term for environmental illnesses) differ from one another according to which tissues are affected. In chronic fatigue syndrome, the NO/ONOO¯ cycle affects the mitochondria; in fibromyalgia, the cycle affects the thalamus; in post-traumatic stress disorder, the cycle affects the hippocampus; and in multiple chemical sensitivity, the cycle affects specific neurotransmitter receptors and causes neural sensitization.
In the fifty-page Chapter 15, Therapy, Dr. Pall reviews the natural substances used to treat CFS, MCS, and fibromyalgia, and presents his protocol (discussed below.)
Dr. Pall's book is closely argued from the evidence of hundreds of studies in biochemical and medical journals.
The Neural Sensitization Protocol was designed by Dr. Martin Pall, PhD and Dr. Grace Ziem, MD, to address neural sensitization in environmental illness. It involves nebulized glutathione and vitamin B12, and approximately two dozen nutritional supplements believed to be synergistic in down-regulating the nitric oxide cycle.
Besides the information in Dr. Pall's book, the protocol is also described on the web:
The Pall Protocol for Treating CFS/ME
by Erica Verrillo, ProHealth
Supplements in ME/CFS by Prof. Martin Pall
European Society for ME
Key Pharmacy, in Washington State, compounds the protocol and has further information.
Dr. Pall worked with Nutricology to formulate a version of the oral protocol.
Nutricology: Martin Pall Products
Elsewhere, Dr. Pall has discussed the danger of one component of the Neural Sensitization Protocol, alpha lipoic acid, for those who have body stores of mercury.
According to Andrew Cutler, PhD, in his book Amalgam Illness, Diagnosis and Treatment : What You Can Do to Get Better, How Your Doctor Can Help , alpha lipoic acid is a powerful chelator of mercury into and out of the central nervous system, and uninformed use can make you very sick. He says that it should be used only in a controlled way at the appropriate time.
Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained'
Q&A with Martin L. Pall, PhD
with Martin L. Pall, PhD-July 6, 2007:
Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia
& Suggested Protocol
Conversation with MCS Researcher Martin Pall
by Linda Powers, Townsend Letter for Doctors and Patients, Aug.-Sept. 2005
Dr. Pall's profile on ResearchGate includes a list of his publications, many of which can be downloaded as PDFs.
Martin Pall on ResearchGate
ResearchGate is a social networking platform for academic, corporate, government, and medical researchers.
Sensitization and Stimulation by Peroxynitrite, Nitric Oxide, and
Organic Solvents as the Mechanism of Chemical Sensitivity in
Multiple Chemical Sensitivity
by Martin L. Pall, The FASEB Journal, 2002 (abstract)
Oxide/Peroxynitrite Theory of Multiple Chemical Sensitivity: Central
Role of N-Methyl-D-Aspartate Receptors in the Sensitivity
by Martin L. Pall, Envronmental Health Perspectives, September 2003
Receptor as a Putative Target of Diverse Chemicals in Multiple
by Julius H. Anderson and Martin L. Pall, Archives of Environmental Health, 2004 (abstract)