Health and Environmental Illness

Resources about environmental illness and non-drug treatments

Neural Sensitization Protocol - Martin Pall

Dr. Martin Pall, PhD (Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University) fused the theory of neural sensitization with a new disease paradigm. With Dr. Grace Ziem, MD, he developed a non-drug treatment protocol for environmental illness.

Martin Pall on ResearchGate


The Neural Sensitization Protocol was designed by Dr. Martin Pall, PhD and Dr. Grace Ziem, MD, to address neural sensitization. It involves nebulized glutathione and vitamin B12, and approximately two dozen nutritional supplements believed to be synergistic in down-regulating the nitric oxide cycle.

New Treatment for Chemical Injury and Chemical Sensitivity
by Dr. Grace Ziem, M.D.,

Treating Chemical Injury: Step By Step
by Dr. Grace Ziem, M.D.

Chemical Injury Treatment Ingredients
by Dr. Grace Ziem, M.D.

The Pall Protocol for Treating CFS/ME
by Erica Verrillo, ProHealth

Supplements in ME/CFS by Prof. Martin Pall
European Society for ME

Nutricology: Martin Pall Products


Elsewhere, Dr. Pall has discussed the danger of one component of the Neural Sensitization Protocol, alpha lipoic acid, for those who have body stores of mercury.

According to Andrew Cutler, PhD, in his book Amalgam Illness, Diagnosis and Treatment : What You Can Do to Get Better, How Your Doctor Can Help , alpha lipoic acid is a powerful chelator of mercury into and out of the central nervous system, and uninformed use can make you very sick. He says that it should be used only in a controlled way at the appropriate time.


Book: Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome

In Explaining Unexplained Illnesses, Dr. Pall outlines a new disease paradigm: a vicious cycle of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO¯) and the effects on various tissues. The cycle is extremely complex but involves what he describes as "well-established" and "known biochemical sequences."

The symptoms of the multisystem illnesses (his term for environmental illnesses) differ from one another according to which tissues are affected. In chronic fatigue syndrome, the NO/ONOO¯ cycle affects the mitochondria; in fibromyalgia, the cycle affects the thalamus; in post-traumatic stress disorder, the cycle affects the hippocampus; and in multiple chemical sensitivity, the cycle affects specific neurotransmitter receptors and causes neural sensitization.

Dr. Pall's book is closely argued from the evidence of hundreds of studies in biochemical and medical journals.


Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained' Illness?
Q&A with Martin L. Pall, PhD


Live Chat with Martin L. Pall, PhD-July 6, 2007:
Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia
& Suggested Protocol


A Conversation with MCS Researcher Martin Pall
by Linda Powers, Townsend Letter for Doctors and Patients, Aug.-Sept. 2005

Journal Articles

Martin Pall on ResearchGate

NMDA Sensitization and Stimulation by Peroxynitrite, Nitric Oxide, and Organic Solvents as the Mechanism of Chemical Sensitivity in Multiple Chemical Sensitivity
by Martin L. Pall, The FASEB Journal, 2002 (abstract)

Elevated Nitric Oxide/Peroxynitrite Theory of Multiple Chemical Sensitivity: Central Role of N-Methyl-D-Aspartate Receptors in the Sensitivity Mechanism
by Martin L. Pall, Envronmental Health Perspectives, September 2003

The Vanilloid Receptor as a Putative Target of Diverse Chemicals in Multiple Chemical Sensitivity
by Julius H. Anderson and Martin L. Pall, Archives of Environmental Health, 2004 (abstract)

Updated 9/6/2016