Neural Sensitization Protocol
Dr. Martin Pall, PhD (Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University) has fused the theory of neural sensitization with a new disease paradigm. With Dr. Grace Ziem, MD, he has developed a non-drug treatment protocol for environmental illness.
TheTenthParadigm.org
Home page of Dr. Martin Pall, Research Director of the Tenth Paradigm
Research Group
Treatment
The Neural Sensitization Protocol was designed by Dr. Martin Pall, PhD and Dr. Grace Ziem, MD, to address neural sensitization. It involves nebulized glutathione and vitamin B12, and approximately two dozen nutritional supplements believed to be synergistic in down-regulating the nitric oxide cycle.
Therapy by Martin L. Pall, PhD
New
Treatment for Chemical Injury and Chemical Sensitivity
by Dr. Grace Ziem, MD, ChemicalInjury.net
Treating Chemical Injury: Step By Step
Chemical Injury Treatment Ingredients
Caution
At the end of the following article, Dr. Pall discusses the danger of one component of the Neural Sensitization Protocol, alpha lipoic acid, for those who have body stores of mercury.
Allergy
Research Group Protocol
by Martin L. Pall, PhD
According to Andrew Cutler, PhD, in his book Amalgam Illness, alpha lipoic acid is a powerful chelator of mercury into and out of the central nervous system, and uninformed use can make you very sick. He says that it should be used only in a controlled way at the appropriate time.
Research
In Explaining "Unexplained Illnesses", Dr. Pall outlines a new disease paradigm: a vicious cycle of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO¯) and the effects on various tissues. The cycle is extremely complex but involves what he describes as "well-established" and "known biochemical sequences."
The symptoms of the multisystem illnesses (his term for environmental illnesses) differ from one another according to which tissues are affected. In chronic fatigue syndrome, the NO/ONOO¯ cycle affects the mitochondria; in fibromyalgia, the cycle affects the thalamus; in post-traumatic stress disorder, the cycle affects the hippocampus; and in multiple chemical sensitivity, the cycle affects specific neurotransmitter receptors and causes neural sensitization.
Dr. Pall's book is closely argued from the evidence of hundreds of studies in biochemical and medical journals.
Interviews
Nitric
Oxide Cycle Theory: Will It Explain CFS, FM, and Other
'Unexplained' Illness?
Q&A with Martin L. Pall, PhD
by ProHealth.com
Live
Chat with Martin L. Pall, PhD-July 6, 2007:
Professor of Biochemistry Explains Mechanisms of Chronic Fatigue
Syndrome and Fibromyalgia
& Suggested Protocol
from ProHealth.com
A
Conversation with MCS Researcher Martin Pall
by Linda Powers, Townsend Letter for Doctors and Patients,
Aug.-Sept. 2005
Journal Articles
NMDA
Sensitization and Stimulation by Peroxynitrite, Nitric Oxide, and
Organic Solvents as the Mechanism of Chemical Sensitivity in Multiple
Chemical Sensitivity
by Martin L. Pall, The FASEB Journal, 2002
Elevated
Nitric Oxide/Peroxynitrite Theory
of Multiple Chemical Sensitivity: Central Role of N-Methyl-D-Aspartate
Receptors in the Sensitivity
Mechanism
by Martin L. Pall, Envronmental Health Perspectives,
September 2003
The
Vanilloid Receptor as a Putative Target of Diverse Chemicals in
Multiple Chemical Sensitivity
by Julius H. Anderson and Martin L. Pall, Archives of
Environmental Health, 2004