Neural Sensitization Protocol
Dr. Martin Pall, PhD, Washington State University, has fused the theory of neural sensitization with a new disease paradigm. With Dr. Grace Ziem, MD, he has developed a non-drug treatment protocol for environmental illness.
Treatment
The Neural Sensitization Protocol was designed by Dr. Martin Pall, PhD and Dr. Grace Ziem, MD, to address neural sensitization. It involves nebulized glutathione and vitamin B12, and approximately twenty nutritional supplements believed to be synergistic in down-regulating the nitric oxide cycle.
New
Treatment for Chemical Injury and Chemical Sensitivity
by Dr. Grace Ziem, MD, ChemicalInjury.net
Treating Chemical Injury: Step By Step
Chemical Injury Treatment Ingredients
Research
In Explaining "Unexplained Illnesses", Dr. Pall outlines a new disease paradigm: a vicious cycle of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO¯) and the effects on various tissues. The cycle is extremely complex but involves what he describes as "well-established" and "known biochemical sequences."
The symptoms of the multisystem illnesses (his term for environmental illnesses) differ from one another according to which tissues are affected. In chronic fatigue syndrome, the NO/ONOO¯ cycle affects the mitochondria; in fibromyalgia, the cycle affects the thalamus; in post-traumatic stress disorder, the cycle affects the hippocampus; and in multiple chemical sensitivity, the cycle affects specific neurotransmitter receptors and causes neural sensitization.
Dr. Pall's book is closely argued from the evidence of hundreds of studies in biochemical and medical journals.
Interviews
Nitric
Oxide Cycle Theory: Will It Explain CFS, FM, and Other
'Unexplained' Illness?
Q&A with Martin L. Pall, PhD
by ProHealth.com
Live
Chat with Martin L. Pall, PhD-July 6, 2007:
Professor of Biochemistry Explains Mechanisms of Chronic Fatigue
Syndrome and Fibromyalgia
& Suggested Protocol
from ProHealth.com
A
Conversation with MCS Researcher Martin Pall
by Linda Powers, Townsend Letter for Doctors and Patients,
Aug.-Sept. 2005
Summary
Novel
Disease Paradigm Produces Explanations for a Whole Group of Illnesses
by Martin L. Pall
Dr. Pall's summary includes a discussion of the treatment
protocol. He quotes Dr. Ziem as calling the protocol the "most
significant
medical advance ever for chemical injury."
Journal Articles
NMDA
Sensitization and Stimulation by Peroxynitrite, Nitric Oxide, and
Organic Solvents as the Mechanism of Chemical Sensitivity in Multiple
Chemical Sensitivity
by Martin L. Pall, The FASEB Journal, 2002
Elevated
Nitric Oxide/Peroxynitrite Theory
of Multiple Chemical Sensitivity: Central Role of N-Methyl-D-Aspartate
Receptors in the Sensitivity
Mechanism
by Martin L. Pall, Envronmental Health Perspectives,
September 2003
The
Vanilloid Receptor as a Putative Target of Diverse Chemicals in
Multiple Chemical Sensitivity
by Julius H. Anderson and Martin L. Pall, Archives of
Environmental Health, 2004
Unanswered Questions
The nitric oxide / peroxynitrite paradigm needs to be integrated with the biology of chronic mercury poisoning.
One component of the Neural Sensitization Protocol is alpha lipoic acid. According to Andrew Cutler, PhD, in his book Amalgam Illness, alpha lipoic acid is a powerful chelator of mercury into and out of the central nervous system, and uninformed use can make you very sick. He says that it should be used only in a controlled way at the appropriate time. This appears to not be widely known. A discussion also appeared in a Nutricology newsletter that is apparently no longer on Nutricology's web site.