Mitochondrial Dysfunction
Chronic Fatigue Syndrome
Dr. Sarah Myhill, MD states, "Chronic fatigue syndrome is the symptom caused by mitochondrial failure." The mitochondrion is the structure in the biological cell that supplies energy to the cell. Mitochondrial dysfunction can affect every cell of the body, including the cells of the heart.
CFS
is Low Output Heart Failure Secondary to Mitochondrial Failure
By Dr. Sarah Myhill, MD
Abnormal
Impedance Cardiography Predicts Symptom Severity in Chronic Fatigue
Syndrome
by Arnold Peckerman, PhD, et al, The American Journal of
the Medical Sciences, August 2003
(See Cardiac Insufficiency)
The source of the mitochondrial dysfunction may be the upregulation of the nitric oxide/peroxynitrite cycle, according to the theory developed by Dr. Martin Pall, PhD. (See Neural Sensitization Protocol)
Chronic
Fatigue Syndrome as a NO/ONOO¯ Cycle Disease
by Martin L. Pall, PhD
Dr. Paul Cheney, MD, discusses energy production in a portion of the following lecture. Measurements of mitochondrial function in CFS patients showed "significant derangement" that he describes as a generalized brown-out. This suggests to him a metabolic cause. (See Defects of Detoxification)
Lecture
by Paul Cheney, MD, PhD, February 1999
Notes by Sue Bailey
Dr. David Bell describes reasons to believe that chronic fatigue syndrome, characterized by post-exertional malaise, is a type of mitochondrial disease (see Mitochondrial Cytopathy below) that has not been properly studied.
Chronic
Fatigue Syndrome as a Mitochondrial Disease?
by Dr. David S. Bell, MD
Mitochondrial Function
The following article discusses nutrients shown by scientific research to improve mitochondrial function (includes 56 references).
Mitochondria
and the Evolution of Human Longevity
Life Extension Magazine, February 2006
The following article includes research about multiple sclerosis, chronic fatigue syndrome, neuropathy, and depression:
Why
Aging Humans Need More Carnitine
by Julius G. Goepp, MD, Life Extension Magazine,
September 2006
CoQ10's
"Other" Health Benefits
by Sherry Kahn, Life Extension Magazine,
February 2006
CoQ10's
New Benefits
Life Extension Magazine, August 2006
Mitochondrial Damage
Medication-Induced
Mitochondrial Damage and Disease
by John Neustadt and Dr. Steve Pieczenik, MD, July 17, 2008
Mitochondrial Cytopathy
Cleveland Clinical Journal of Medicine, July 2001
- Mitochondrial
Cytopathy in Adults: What We Know So Far
By Dr. Bruce H. Cohen, MD, and Dr. Deborah R. Gold, MD
Cardiovascular Disease
Dr. Myhill's article above refers to cardiologist Dr. Stephen Sinatra, who recommends the same supplements for mitochondrial dysfunction in the heart as he recommends for chronic fatigue syndrome. All forms of cardiovascular disease--coronary artery disease, arrhythmias, congestive heart failure, and cardiomyopathy--respond to these supplements. Anyone with heart disease should not delay in obtaining Dr. Sinatra's book.
Book:
The Sinatra Solution: Metabolic Cardiology
by Dr. Stephen T. Sinatra, MD
Review
of The Sinatra Solution
by Heidi Boudro, HeidiBoudro.com
How
Many Americans Are Magnesium Deficient?
by William Faloon, Life Extension Magazine,
September 2005